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Article

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.

Molecular systems biology - 24 May 2011

Fritsche-Guenther Raphaela, Witzel Franziska, Sieber Anja, Herr Ricarda, Schmidt Nadine, Braun Sandra, Brummer Tilman, Sers Christine, Blüthgen Nils

Abstract excerpt

Protein levels within signal transduction pathways vary strongly from cell to cell. Here, we analysed how signalling pathways can still process information quantitatively despite strong heterogeneity in protein levels. We systematically perturbed the protein levels of Erk, the terminal kinase in the MAPK signalling pathway in a panel of human cell lines. We found that the steady-state phosphorylation of Erk is...

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Share to Extracellular Signal-Regulated MAP Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to MAP Kinase Signaling System

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Share to Proto-Oncogene Proteins c-raf

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Source

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Identifiers

PMID: 21613978
DOI: 10.1038/msb.2011.27
PMCID: PMC3130559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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