Article

Sporadic ERK pulses drive non-genetic resistance in drug-adapted BRAF <sup>V600E</sup> melanoma cells

2019-09-08

Abstract excerpt

<h4>SUMMARY</h4> Anti-cancer drugs commonly target signal transduction proteins activated by mutation. In patients with BRAF V600E melanoma, small molecule RAF and MEK kinase inhibitors cause dramatic but often transient tumor regression. Emerging evidence suggests that cancer cells adapting by non-genetic mechanisms constitute a reservoir for the development of drug-resistant tumors. Here, we show that few hour...

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Literature Corpus work: 2e7a32d3-6b8c-5c6a-b279-9986ebc9365c
DOI: 10.1101/762294

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