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Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model

2023-03-25

Abstract excerpt

LYN kinase is expressed in BRCA1 loss-of-function-dependent mouse mammary tumours, in the cells of origin of such tumours, and in human breast cancer. Suppressing LYN kinase activity in BRCA1-defective cell lines, as well as in in vitro cultures of Brca1 -null mouse mammary tumours, is deleterious to their growth. Here, we have examined the interaction between LYN kinase and BRCA1 loss-of-function in an in vivo...

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Literature Corpus work: daf5c2da-b45f-5ea2-a160-9e20119ee0d7
DOI: 10.1101/2023.03.23.533973

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Conditional <i>in vivo</i> deletion of LYN kinase has little effect on a <i>BRCA1</i> loss-of-function-associated mammary tumour model

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