A dominant function of LynB kinase in preventing autoimmunity

Abstract excerpt

Here, we report that the LynB splice variant of the Src-family kinase Lyn exerts a dominant immunosuppressive function in vivo, whereas the LynA isoform is uniquely required to restrain autoimmunity in female mice. We used CRISPR-Cas9 gene editing to constrain lyn splicing and expression, generating single-isoform LynA knockout (LynA KO ) or LynB KO mice. Autoimmune disease in total Lyn KO mice is characterized...

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