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Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis

31 May 2011

Abstract excerpt

The tyrosine kinase c-Src is activated in a large proportion of breast cancers, in which it is thought to play a key role in promoting the malignant phenotype. c-Src activity is also elevated in transgenic mouse models of breast cancer, including the widely used polyomavirus middle-T antigen (PyVmT) model, which provides an opportunity to study the importance of c-Src in mammary tumorigenesis. However, germline...

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PMID: 21628573
DOI: 10.1073/pnas.1018861108

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