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Article

Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors.

Nature communications - 9 Mar 2021

Bach Karsten, Pensa Sara, Zarocsinceva Marija, Kania Katarzyna, Stockis Julie, Pinaud Silvain, Lazarus Kyren A, Shehata Mona, Simões Bruno M, Greenhalgh Alice R, Howell Sacha J, Clarke Robert B, Caldas Carlos, Halim Timotheus Y F, Marioni John C, Khaled Walid T

Abstract excerpt

It is unclear how genetic aberrations impact the state of nascent tumour cells and their microenvironment. BRCA1 driven triple negative breast cancer (TNBC) has been shown to arise from luminal progenitors yet little is known about how BRCA1 loss-of-function (LOF) and concomitant mutations affect the luminal progenitor cell state. Here we demonstrate how time-resolved single-cell profiling of genetically...

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Identifiers

PMID: 33686070
DOI: 10.1038/s41467-021-21783-3
PMCID: PMC7940427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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