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Article

Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models.

The Journal of pathology - 1 Jun 2014

Melchor Lorenzo, Molyneux Gemma, Mackay Alan, Magnay Fiona-Ann, Atienza María, Kendrick Howard, Nava-Rodrigues Daniel, López-García María Ángeles, Milanezi Fernanda, Greenow Kirsty, Robertson David, Palacios José, Reis-Filho Jorge S, Smalley Matthew J

Abstract excerpt

The heterogeneous nature of mammary tumours may arise from different initiating genetic lesions occurring in distinct cells of origin. Here, we generated mice in which Brca2, Pten and p53 were depleted in either basal mammary epithelial cells or luminal oestrogen receptor (ER)-negative cells. Basal cell-origin tumours displayed similar histological phenotypes, regardless of the depleted gene. In contrast, luminal...

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Share to BRCA2 Protein
Share to Carcinoma, Ductal, Breast

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

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Share to Mammary Glands, Animal

Share to PTEN Phosphohydrolase

Share to Receptors, Estrogen

Source

Identifiers

PMID: 24615332
DOI: 10.1002/path.4345

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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