Article
A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2009
Verhagen Anne M, Wallace Morgan E, Goradia Ankita, Jones Sarah A, Croom Hayley A, Metcalf Donald, Collinge Janelle E, Maxwell Mhairi J, Hibbs Margaret L, Alexander Warren S, Hilton Douglas J, Kile Benjamin T, Starr Robyn
Abstract excerpt
Lyn kinase, a member of the Src family of tyrosine kinases, functions as both a positive and negative regulator of B cell activation. In the absence of Lyn, BCR signaling is unregulated, leading to perturbed B cell development, hyperactive B cells, and lethal Ab-mediated autoimmune disease. We have generated a mutant mouse pedigree, termed Mld4, harboring a novel mutation in the gene encoding Lyn, which renders...
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