Effects of heterozygosity for the Rb-1t19neo allele in the mouse.

Article

Effects of heterozygosity for the Rb-1t19neo allele in the mouse.

Oncogene - 20 Apr 1995

Harrison D J, Hooper M L, Armstrong J F, Clarke A R

Abstract excerpt

We describe the pathology of a cohort of 80 mice heterozygous for an inactive allele of the Rb-1 tumour suppressor gene. The majority of these mice developed locally invasive tumours, arising from the pituitary gland. The time of onset of overt signs of disease in mice known to have inherited the...

Topics

Alleles
Animals
Genes, Retinoblastoma
Genes, p53
Heterozygote
Life Expectancy
Mice
Mice, Inbred BALB C
Pituitary Neoplasms
Pro-Opiomelanocortin

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