Article
Effects of heterozygosity for the Rb-1t19neo allele in the mouse.
Oncogene - 20 Apr 1995
Harrison D J, Hooper M L, Armstrong J F, Clarke A R
Abstract excerpt
We describe the pathology of a cohort of 80 mice heterozygous for an inactive allele of the Rb-1 tumour suppressor gene. The majority of these mice developed locally invasive tumours, arising from the pituitary gland. The time of onset of overt signs of disease in mice known to have inherited their mutant allele paternally shows a small but statistically significant shift to the lower end of the spectrum,...
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