Article
Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation.
Immunity - 1 Jul 1997
Chan V W, Meng F, Soriano P, DeFranco A L, Lowell C A
Abstract excerpt
Lyn-deficient mice were generated to analyze the role of Lyn in B cell antigen receptor (BCR) signaling. These mice had a reduced number of peripheral B cells with a greater proportion of immature cells and a higher than normal turnover rate. Aged lyn-/- mice developed splenomegaly, produced auto...
Topics
- Aging
- Animals
- Antibodies, Anti-Idiotypic
- Antigens, CD
- Autoantibodies
- B-Lymphocytes
- B7-2 Antigen
- Calcium-Calmodulin-Dependent Protein Kinases
- Chickens
- Down-Regulation
- Lipopolysaccharides
- Membrane Glycoproteins
- Mice
- Phenotype
- Phosphorylation
- Pseudogenes
- Receptors, IgG
- Signal Transduction