Article
Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage.
Immunity - 1 Oct 2001
Harder K W, Parsons L M, Armes J, Evans N, Kountouri N, Clark R, Quilici C, Grail D, Hodgson G S, Dunn A R, Hibbs M L
Abstract excerpt
To investigate the role of the Lyn kinase in establishing signaling thresholds in hematopoietic cells, a gain-of-function mutation analogous to the Src Y527F-activating mutation was introduced into the Lyn gene. Intriguingly, although Lyn is widely expressed within the hematopoietic system, these mice displayed no propensity toward hematological malignancy. By contrast, analysis of aging cohorts of both loss- and...
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