Article
Analysis of large and small colony L5178Y tk-/- mouse lymphoma mutants by loss of heterozygosity (LOH) and by whole chromosome 11 painting: detection of recombination.
Mutagenesis - 1 Sept 1998
Liechty M C, Scalzi J M, Sims K R, Crosby H, Spencer D L, Davis L M, Caspary W J, Hozier J C
Abstract excerpt
Analysis of 122 spontaneous large and small colony mutants derived from L5178Y tk +/- mouse lymphoma cells at 28 heteromorphic microsatellite loci on chromosome 11 showed that extensive loss of heterozygosity (LOH) is common in both large colony and small colony mutants, eliminating most chromoso...
Topics
- Aneuploidy
- Animals
- Cell Division
- Chromosome Aberrations
- Chromosome Painting
- Clone Cells
- Leukemia L5178
- Loss of Heterozygosity
- Mice
- Mutation
- Neoplasm Proteins
- Recombination, Genetic
- Sequence Deletion
- Thymidine Kinase