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Article

Analysis of large and small colony L5178Y tk-/- mouse lymphoma mutants by loss of heterozygosity (LOH) and by whole chromosome 11 painting: detection of recombination.

Mutagenesis - 1 Sept 1998

Liechty M C, Scalzi J M, Sims K R, Crosby H, Spencer D L, Davis L M, Caspary W J, Hozier J C

Abstract excerpt

Analysis of 122 spontaneous large and small colony mutants derived from L5178Y tk +/- mouse lymphoma cells at 28 heteromorphic microsatellite loci on chromosome 11 showed that extensive loss of heterozygosity (LOH) is common in both large colony and small colony mutants, eliminating most chromosome 11 loci as candidates for a putative growth control locus. These results, in conjunction with historical cytogenetic...

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Identifiers

PMID: 9800191
DOI: 10.1093/mutage/13.5.461

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Analysis of large and small colony L5178Y tk-/- mouse lymphoma mutants by loss of heterozygosity (LOH) and by whole chromosome 11 painting: detection of recombination.PMID 9800191Read ↗

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