Article

Splice-specific <i>lyn</i> knockout mice reveal a dominant function of LynB in preventing autoimmunity

2021-05-04

Abstract excerpt

The unique roles of the Src-family kinases LynA and LynB in immune activating and inhibitory signaling have eluded definition. Here we report that LynB, the shorter splice product of lyn , carries the dominant immunosuppressive function. We used CRISPR/Cas9 gene editing to constrain lyn splicing and expression to a single product: LynA KO or LynB KO mice. While activities of both isoforms regulate homeostatic...

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Literature Corpus work: 169aef0e-e6ac-5bc8-95a4-bd0559073b99
DOI: 10.1101/2021.05.03.439514

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