Article
Misfolded α-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells
2019-06-07
Abstract excerpt
The misfolding and aggregation of the largely disordered protein, α-synuclein, is a central pathogenic event that occurs in the synucleinopathies; a group of neurodegenerative disorders that includes Parkinson’s disease. While there is a clear link between protein misfolding and neuronal vulnerability, the precise pathogenic mechanisms employed by disease-associated α-synuclein are unresolved. Here, we studied the...
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Identifiers and source
- Literature Corpus work
- dae3b60d-e461-5b84-91a1-01f95d55c656
- DOI
- 10.1101/663815