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Article

Cell systems and the toxic mechanism(s) of alpha-synuclein.

Experimental neurology - 1 Jan 2008

Cookson Mark R, van der Brug Marcel

Abstract excerpt

Mutations in the SNCA gene are causal for familial Parkinson disease/Lewy body disease. alpha-Synuclein is a small acidic protein that binds loosely to the surface of vesicles and may play a role in synaptic dynamics, although its normal function remains somewhat unclear. What is clear is that point mutations or increased expression of wild type alpha-synuclein causes disease. A great deal of literature supports...

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Source

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Identifiers

PMID: 17603039
DOI: 10.1016/j.expneurol.2007.05.022
PMCID: PMC2231843

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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