Article

Alpha-synuclein fibrils induce budding of mitochondrial-derived vesicles

2025-10-15

Abstract excerpt

α-synuclein (α-syn) aggregation is a hallmark of synucleinopathies, a class of neurodegenerative disorders such as Parkinson’s disease (PD). Several lines of evidence indicate the involvement of mitochondria in the disease pathology. Despite extensive study, the link between α-syn aggregation and mechanisms of mitochondrial toxicity remains not fully understood. Using high-resolution imaging with electron microsco...

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Literature Corpus work: 60c3d9cc-47b7-56d4-a7d2-905cc71eafd8
DOI: 10.1101/2025.10.13.682220

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