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Article

Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein.

Nature communications - 26 Feb 2018

Ryan Tammy, Bamm Vladimir V, Stykel Morgan G, Coackley Carla L, Humphries Kayla M, Jamieson-Williams Rhiannon, Ambasudhan Rajesh, Mosser Dick D, Lipton Stuart A, Harauz George, Ryan Scott D

Abstract excerpt

Neuronal loss in Parkinson's disease (PD) is associated with aberrant mitochondrial function and impaired proteostasis. Identifying the mechanisms that link these pathologies is critical to furthering our understanding of PD pathogenesis. Using human pluripotent stem cells (hPSCs) that allow comparison of cells expressing mutant SNCA (encoding α-synuclein (α-syn)) with isogenic controls, or SNCA-transgenic mice,...

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Source

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Identifiers

PMID: 29483518
DOI: 10.1038/s41467-018-03241-9
PMCID: PMC5827019

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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