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α-Synuclein: A Promising Biomarker for Parkinson’s Disease and Related Disorders

9 Apr 2024

Abstract excerpt

Mutations in the SNCA gene, which encodes α-synuclein (α-syn), play a key role in the development of genetic Parkinson's disease (PD). α-Syn is a major component of Lewy bodies in PD and glial cytoplasmic inclusions in multiple system atrophy (MSA). Rapid eye movement sleep behavior disorder patients often progress to PD, dementia with Lewy bodies, or MSA, which are collectively known as α-synucleinopathies. The...

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PMID: 38589016
DOI: 10.14802/jmd.24075

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