Article

An interdisciplinary approach to studying mechanistic, structural and toxic features of protein aggregates associated with neurodegenerative disorders

2018-01-01

Abstract excerpt

The misfolding and aggregation of proteins is closely associated with more than fifty human disorders, including Alzheimer's and Parkinson's diseases, all of which are currently incurable and many represent a major threat to human life. The mechanism of protein aggregation is subject to extensive studies. The damaging effects associated with protein aggregation have been attributed to amyloidogenic species that ar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 11cc7a6f-aa47-5595-a298-4aa501df13ba
DOI: 10.17863/cam.21466

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An interdisciplinary approach to studying mechanistic, structural and toxic features of protein aggregates associated with neurodegenerative disordersDOI 10.17863/cam.21466Read

Biophysical approaches to characterising protein-protein interactions and intermediate species in protein aggregationSemantic proximity Read

Protein misfolding, aggregation and mechanism of amyloid cytotoxicity: An overview and therapeutic strategies to inhibit aggregationSemantic proximity Read

The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseasesSemantic proximity Read

Amyloid fibril polymorphism: a challenge for molecular imaging and therapySemantic proximity Read

Protein aggregation and deposition: implications for ion channel formation and membrane damage.Semantic proximity Read

Mitigating protein aggregation to reduce the toxicity inherent to Parkinson's and Alzheimer's diseasesSemantic proximity Read

Molecular determinants of protein pathogenicity at the single-aggregate levelSemantic proximity Read

Protein misfolding in Alzheimer’s and Parkinson’s disease: genetics and molecular mechanismsSemantic proximity Read

Neurodegenerative disorders of protein aggregationSemantic proximity Read

Amyloidogenesis in its biological environment: challenging a fundamental issue in protein misfolding diseasesSemantic proximity Read

Structural mechanisms of oligomer and amyloid fibril formation by the prion protein.Semantic proximity Read

Protein misfolding in the late-onset neurodegenerative diseases: common themes and the unique case of amyotrophic lateral sclerosis.Semantic proximity Read