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Article

Clues to how alpha-synuclein damages neurons in Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2010

Sulzer David

Abstract excerpt

Alpha-synuclein (alpha-syn) appears to normally regulate neurotransmitter release, possibly via calcium-dependent binding and dissociation from lipid domains on secretory vesicles. The pathogenic effects of alpha-syn leading to Parkinson's disease (PD) appear to result from alternate toxic effects on lipid membrane. A variety of findings indicate that overexpression of wild-type alpha-syn, pathogenic mutations of...

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PMID: 20187229
DOI: 10.1002/mds.22639

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