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Article

Seeking a mechanism for the toxicity of oligomeric α-synuclein.

Biomolecules - 25 Mar 2015

Roberts Hazel L, Brown David R

Abstract excerpt

In a number of neurological diseases including Parkinson's disease (PD), α-synuclein is aberrantly folded, forming abnormal oligomers, and amyloid fibrils within nerve cells. Strong evidence exists for the toxicity of increased production and aggregation of α-synuclein in vivo. The toxicity of α-synuclein is popularly attributed to the formation of "toxic oligomers": a heterogenous and poorly characterized group...

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Identifiers

PMID: 25816357
DOI: 10.3390/biom5020282
PMCID: PMC4496673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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