A30P and A30G Mutations in α-Synuclein Promote Metastable Long-Lived Aggregates with Distinct Structural Responses to EGCG.

Abstract excerpt

Synucleinopathies are neurodegenerative disorders marked by the accumulation of misfolded α-synuclein and its familial mutants in brain cells. The mechanistic understanding of how α-synuclein mutations exacerbate disease remains unsolved. Here, the in vitro aggregation kinetics of α-synuclein and its mutants revealed that A30P and a recently discovered A30G variant displayed aggregation kinetics...

Topics

Join the communities discussing this publication.

• alpha-Synuclein
• Amyloid
• Catechin
• AFM gene
• Kinetics
• Mutation