Article

Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregation

2020-11-09

Abstract excerpt

<h4>ABSTRACT</h4> Intraneuronal accumulation of aggregated α-synuclein is a pathological hallmark of Parkinson’s disease. Therefore, mechanisms capable of promoting α-synuclein deposition bear important pathogenetic implications. Mutations of the glucocerebrosidase 1 ( GBA ) gene represent a prevalent Parkinson’s disease risk factor. They are associated with loss of activity of a key enzyme involved in lipid met...

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Literature Corpus work: cc6994ea-5da1-5712-a18b-c66325e8e298
DOI: 10.1101/2020.11.09.375048

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