Article

Phosphorylation-dependent tuning of mRNA deadenylation rates

2024-10-19

Abstract excerpt

mRNA decay is a major determinant of gene regulation that is controlled through shortening of mRNA poly(A) tails by the Ccr4-Not complex. The specificity of deadenylation can be mediated through RNA adaptors – RNA-binding proteins that tether substrate mRNAs to Ccr4-Not in a regulated and context-specific manner. Interaction with Ccr4-Not is mediated by intrinsically disordered regions (IDRs) within the RNA adapto...

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Literature Corpus work: da67c55d-2f67-59c0-b2b3-dacf52eebb36
DOI: 10.1101/2024.10.18.618793

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