Article
Patterns and plasticity in RNA-protein interactions enable recruitment of multiple proteins through a single site.
Proceedings of the National Academy of Sciences of the United States of America - 17 Apr 2012
Valley Cary T, Porter Douglas F, Qiu Chen, Campbell Zachary T, Hall Traci M Tanaka, Wickens Marvin
Abstract excerpt
mRNA control hinges on the specificity and affinity of proteins for their RNA binding sites. Regulatory proteins must bind their own sites and reject even closely related noncognate sites. In the PUF [Pumilio and fem-3 binding factor (FBF)] family of RNA binding proteins, individual proteins discriminate differences in the length and sequence of binding sites, allowing each PUF to bind a distinct battery of...
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