Article
Targeted translational regulation using the PUF protein family scaffold.
Proceedings of the National Academy of Sciences of the United States of America - 20 Sept 2011
Cooke Amy, Prigge Andrew, Opperman Laura, Wickens Marvin
Abstract excerpt
Regulatory complexes formed on mRNAs control translation, stability, and localization. These complexes possess two activities: one that binds RNA and another--the effector--that elicits a biological function. The Pumilio and FBF (PUF) protein family of RNA binding proteins provides a versatile scaffold to design and select proteins with new specificities. Here, the PUF scaffold is used to target translational...
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