Specific recognition and ubiquitination of slow-moving ribosomes by human CCR4-NOT

Abstract excerpt

Eukaryotic messenger RNA (mRNA) decay is generally initiated by removal of the 3’ polyadenosine (poly(A)) tail by the CCR4-NOT complex. Yeast Ccr4-Not binds and ubiquitinates ribosomes stalled on mRNAs with sub-optimal codons to trigger deadenylation and decay of the associated transcript. However, the mammalian ortholog of the E3 ubiquitin ligase subunit, CNOT4, is not a constitutive component of human CCR4-NOT....

Topics

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• Cathepsin A
• Cytomegalovirus and herpesvirus research
• Enzyme Stability
• Monoclonal and Polyclonal Antibodies Research
• Polyribosomes
• Polyubiquitin
• RNA and protein synthesis mechanisms
• RNA Research and Splicing

Identifiers and source

Literature Corpus work

70dbffe0-3d22-5412-8b3a-476e81f54c67

DOI

10.1101/2022.07.24.501325