Article
The short conserved region-2 of LARP4 interacts with ribosome-associated RACK1 and promotes translation.
Nucleic acids research - 24 Jan 2025
Ranjan Amitabh, Mattijssen Sandy, Charlly Nithin, Gallardo Isabel Cruz, Pitman Leah F, Coleman Jennifer C, Conte Maria R, Maraia Richard J
Abstract excerpt
LARP4 interacts with poly(A)-binding protein (PABP) to protect messenger RNAs (mRNAs) from deadenylation and decay, and recent data indicate it can direct the translation of functionally related mRNA subsets. LARP4 was known to bind RACK1, a ribosome-associated protein, although the specific regions involved and relevance had been undetermined. Here, through a combination of in-cell and in vitro methodologies, we...
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