Article
UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency.
Nucleic acids research - 22 May 2024
Chapman Joseph H, Youle Alice M, Grimme Acadia L, Neuman Keir C, Hogg J Robert
Abstract excerpt
The RNA helicase UPF1 interacts with mRNAs, mRNA decay machinery, and the terminating ribosome to promote nonsense-mediated mRNA decay (NMD). Structural and biochemical data have revealed that UPF1 exists in an enzymatically autoinhibited 'closed' state. Upon binding the NMD protein UPF2, UPF1 undergoes an extensive conformational change into a more enzymatically active 'open' state, which exhibits enhanced...
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