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Article

PUF protein-mediated deadenylation is catalyzed by Ccr4p.

The Journal of biological chemistry - 5 Jan 2007

Goldstrohm Aaron C, Seay Daniel J, Hook Brad A, Wickens Marvin

Abstract excerpt

PUF proteins control gene expression by binding to the 3'-untranslated regions of specific mRNAs and triggering mRNA decay or translational repression. Here we focus on the mechanism of PUF-mediated regulation. The yeast PUF protein, Mpt5p, regulates HO mRNA and stimulates removal of its poly(A) tail (i.e. deadenylation). Mpt5p repression in vivo is dependent on POP2, a component of the cytoplasmic...

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PMID: 17090538
DOI: 10.1074/jbc.M609413200

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PUF protein-mediated deadenylation is catalyzed by Ccr4p.PMID 17090538Read ↗

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The Puf3 protein is a transcript-specific regulator of mRNA degradation in yeast.Semantic proximity Read ↗

The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2.Semantic proximity Read ↗

The RNA binding domain of Pumilio antagonizes poly-adenosine binding protein and accelerates deadenylation.Semantic proximity Read ↗

Phosphorylation-dependent tuning of mRNA deadenylation ratesSemantic proximity Read ↗

Molecular Insights into mRNA Polyadenylation and DeadenylationSemantic proximity Read ↗

Targeted translational regulation using the PUF protein family scaffold.Semantic proximity Read ↗

The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5′ and 3′ Termini of Target mRNAsSemantic proximity Read ↗

A role for the poly(A)-binding protein Pab1p in PUF protein-mediated repression.Semantic proximity Read ↗

Divergent RNA binding specificity of yeast Puf2p.Semantic proximity Read ↗

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