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Molecular Insights into mRNA Polyadenylation and Deadenylation

20 Sept 2022

Abstract excerpt

Poly(A) tails are present on almost all eukaryotic mRNAs, and play critical roles in mRNA stability, nuclear export, and translation efficiency. The biosynthesis and shortening of a poly(A) tail are regulated by large multiprotein complexes. However, the molecular mechanisms of these protein machineries still remain unclear. Recent studies regarding the structural and biochemical characteristics of those protein...

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PMID: 36232288
DOI: 10.3390/ijms231910985

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