Article

Gene-Modulated Network Diffusion for Improved Modeling of Amyloid- <i>β</i> Spread in Alzheimer’s Disease

2026-05-07

Abstract excerpt

Understanding the pathogenesis of amyloid- β pathology in Alzheimer’s Disease (AD) proves to be a challenge. In this work, we expand upon the application of network diffusion models (NDM) to study pathophysiological spread of amyloid- β throughout white matter structural brain networks. We found that the NDM successfully recaptures subpopulation-level spatial patterns (Pearson’s R=0.45-0.48, P FDR < 0.01) of am...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d907e10f-3b28-5637-91dd-b641cca8ba01
DOI: 10.64898/2026.05.04.722725

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene-Modulated Network Diffusion for Improved Modeling of Amyloid- <i>β</i> Spread in Alzheimer’s DiseaseDOI 10.64898/2026.05.04.722725Read

Selective vulnerability and resilience to Alzheimer’s disease tauopathy as a function of genes and the connectomeSemantic proximity Read

Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer’s diseaseSemantic proximity Read

Integrated Transcriptomic and Neuroimaging Brain Model Decodes Biological Mechanisms in Aging and Alzheimer’s DiseaseSemantic proximity Read

Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectomeSemantic proximity Read

Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer’s diseaseSemantic proximity Read

A Joint Tau Propagation and Neuroinflammation Model Reinforces Inflammatory Modulation of Network-Driven Spread in Alzheimer’s DiseaseSemantic proximity Read

Modeling seeding and neuroanatomic spread of pathology in amyotrophic lateral sclerosisSemantic proximity Read

Regional vulnerability in Alzheimer's disease: The role of cell-autonomous and transneuronal processes.Semantic proximity Read

Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genesSemantic proximity Read

Multiscale networks in Alzheimer’s disease identify brain hypometabolism as central across biological scalesSemantic proximity Read

Differentiating amyloid beta spread in autosomal dominant and sporadic Alzheimer’s diseaseSemantic proximity Read

Spatially resolved mapping of tau amplification rates via differentiable simulation of prion-like propagationSemantic proximity Read