Article

Spatially resolved mapping of tau amplification rates via differentiable simulation of prion-like propagation

2026-06-05

Abstract excerpt

Neurodegenerative diseases exhibit characteristic yet heterogeneous patterns of pathological spread, whose underlying determinants remain unclear. A central challenge is that inferring spatially heterogeneous propagation kinetics from neuroimaging data constitutes a high-dimensional inverse problem that has remained intractable at whole-brain scale. Here we present a differentiable reaction–diffusion framework tha...

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Literature Corpus work: d4b31e0e-8ee4-55b2-a300-b386ac71d31d
DOI: 10.64898/2026.06.02.729568

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