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Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes

27 Jul 2022

Abstract excerpt

A key hallmark of Alzheimer’s disease (AD) pathology is the intracellular accumulation of tau protein in the form of neurofibrillary tangles across large-scale networks of the human brain cortex. Currently, it is still unclear how tau accumulates within specific cortical systems and whether in situ genetic traits play a role in this circuit-based propagation progression. In this study, using two independent...

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PMID: 35895837
DOI: 10.1126/scitranslmed.abn7273

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