Article

Integrated Transcriptomic and Neuroimaging Brain Model Decodes Biological Mechanisms in Aging and Alzheimer’s Disease

2021-03-01

Abstract excerpt

<h4>Summary</h4> Both healthy aging and Alzheimer’s disease (AD) are characterized by concurrent alterations in several biological factors. However, generative brain models of aging and AD are limited in incorporating the measures of these biological factors at different spatial resolutions. Here, we propose a personalized bottom-up spatiotemporal brain model which accounts for the direct interplay between hundred...

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Literature Corpus work: 3eb9dffd-2540-5da7-a299-b0b7e0bb97b1
DOI: 10.1101/2021.02.23.21252283

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