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Article

Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectome.

Brain : a journal of neurology - 3 Oct 2025

Anand Chaitali, Abdelnour Farras, Sipes Benjamin, Ma Daren, Maia Pedro D, Torok Justin, Raj Ashish

Abstract excerpt

Brain regions in Alzheimer's disease exhibit distinct vulnerability to its hallmark pathology with the entorhinal cortex and hippocampus succumbing early to tau tangles while others like the primary sensory cortices remain resilient. The quest to understand how local/regional genetic factors, pathogenesis and network-mediated pathology spread, together govern this selective vulnerability (SV) or resilience (SR)...

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Identifiers

PMID: 40631882
DOI: 10.1093/brain/awaf179
PMCID: PMC12493037

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