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Modeling seeding and neuroanatomic spread of pathology in amyotrophic lateral sclerosis

7 Feb 2022

Abstract excerpt

The neurodegenerative disorder amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of upper and lower motor neurons, with pathological involvement of cerebral motor and extra-motor areas in a clinicopathological spectrum with frontotemporal dementia (FTD). A key unresolved issue is how the non-random distribution of pathology in ALS reflects differential network vulnerability, including...

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PMID: 35143975
DOI: 10.1016/j.neuroimage.2022.118968

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