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Article

Regional vulnerability in Alzheimer's disease: The role of cell-autonomous and transneuronal processes.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2018

Acosta Diana, Powell Fontasha, Zhao Yize, Raj Ashish

Abstract excerpt

INTRODUCTION: The stereotypical progression of Alzheimer's disease (AD) pathology is not fully understood. The selective impact of AD on distinct regions has led the field to question if innate vulnerability exists. This study aims to determine if the causative factors of regional vulnerability are dependent on cell-autonomous or transneuronal (non-cell autonomous) processes. METHODS: Using mathematical and...

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Identifiers

PMID: 29306583
DOI: 10.1016/j.jalz.2017.11.014
PMCID: PMC5994366

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