Article

Selective vulnerability and resilience to Alzheimer’s disease tauopathy as a function of genes and the connectome

2024-03-08

Abstract excerpt

<h4>ABSTRACT</h4> Brain regions in Alzheimer’s (AD) exhibit distinct vulnerability to the disease’s hallmark pathology, with the entorhinal cortex and hippocampus succumbing early to tau tangles while others like primary sensory cortices remain resilient. The quest to understand how local/regional genetic factors, pathogenesis, and network-mediated spread of pathology together govern this selective vulnerability...

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Literature Corpus work: 34c94dac-17b1-57eb-97c2-41817be69bc6
DOI: 10.1101/2024.03.04.583403

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