Article

Cytoplasmic DNA Sensing Links LINE-1 Expression to Neuronal Senescence in Alzheimer’s Disease

2026-07-28

Abstract excerpt

Cellular senescence contributes to neurodegeneration in Alzheimer’s disease (AD), yet brain-penetrant senotherapeutic strategies remain limited. Here, we identify long interspersed nuclear element 1 (LINE-1) retrotransposons as key regulators of neuronal senescence and the senescence-associated-secretory-phenotype (SASP) in AD. Using transdifferentiated induced neurons (iNs) that preserve donor-specific aging-asso...

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Literature Corpus work: d904ca3b-05e7-5373-860d-263988cd3391
DOI: 10.64898/2026.07.27.740588

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