Article

Characterization of Cellular Senescence in Primary Human Astrocytes

2026-05-01

Abstract excerpt

Senescent astrocytes have been identified in the brains of patients with neurodegenerative disorders, including Alzheimer’s disease, yet the molecular characteristics of replicative senescence in human astrocytes remain largely unexplored. Prior work has been hampered by the low proliferative capacity and limited telomere shortening of primary human astrocytes in culture. Here, we describe a culture system in whic...

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Literature Corpus work: d85a8f76-1e7e-5f0d-b84c-415197910d31
DOI: 10.64898/2026.04.29.721581

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