Article

DNA damage drives a unique, Alzheimer’s disease-relevant senescent state in neurons

2026-04-03

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) shares molecular hallmarks with the canonical drivers of cellular senescence. Senescent cells have also been shown to accumulate in the brain with age, yet the mechanisms linking AD pathology to the accumulation of senescent cells in the brain remain unclear. Here, we demonstrate that DNA damage in patient-derived directly induced neurons (iNs) drives a senescent-like ce...

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Literature Corpus work: 7acf24e9-30e1-5e3a-96ca-64a2842e0fcd
DOI: 10.64898/2026.04.02.716205

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