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<i>JUN</i> upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s disease

2022-11-24

Abstract excerpt

Adult neurogenic decline, inflammation, and neurodegeneration are phenotypic hallmarks of Alzheimer’s disease (AD). Mobilization of transposable elements (TEs) in heterochromatic regions was recently reported in AD, but the underlying mechanisms are still underappreciated. Combining functional genomics with differentiation of familial and sporadic AD patient derived-iPSCs into hippocampal progenitors, CA3 neurons,...

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Literature Corpus work
ac9f7760-091b-5720-b2e3-f55a100f1276
DOI
10.1101/2022.11.24.517794
Open publication

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<i>JUN</i> upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s diseaseDOI 10.1101/2022.11.24.517794
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