Article

Retrotransposon Activation in the Aged and Alzheimer’s Disease Brain Examined by Nanopore Long-read DNA Sequencing

2025-12-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Cellular defenses against retrotransposable elements (RTEs) weaken with age and RTEs have been reported to contribute to Alzheimer’s disease (AD) pathogenesis by promoting neuroinflammation. The mechanisms implicated include DNA damage promoted by retrotransposition and interferon system activation by RTE-derived cDNA intermediates. LINE-1 (L1) retrotransposons are of partic...

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Literature Corpus work: e7339f61-b1a7-53c4-a5b7-a1ab07eb07ac
DOI: 10.64898/2025.12.12.693943

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