Article

Neurons burdened by DNA double strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration

2021-12-23

Abstract excerpt

DNA double strand breaks (DSBs) are linked to aging, neurodegeneration, and senescence 1,2 . However, the role played by neurons burdened with DSBs in disease-associated neuroinflammation is not well understood. Here, we isolate neurons harboring DSBs from the CK-p25 mouse model of neurodegeneration through fluorescence-activated nuclei sorting (FANS), and characterize their transcriptomes using single-nucleus, b...

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Literature Corpus work: a57a86ef-9f5d-54af-b507-ae1551026743
DOI: 10.1101/2021.12.23.474002

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