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Expansion of highly interferon‐responsive T cells in early‐onset Alzheimer's disease

3 Jun 2024

Abstract excerpt

Abstract INTRODUCTION Altered immune signatures are emerging as a central theme in neurodegenerative disease, yet little is known about immune responses in early‐onset Alzheimer's disease (EOAD). METHODS We examined single‐cell RNA‐sequencing (scRNA‐seq) data from peripheral blood mononuclear cells (PBMCs) and droplet digital polymerase chain reaction (ddPCR) data from CD4 T cells from participants with EOAD and...

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PMID: 38829682
DOI: 10.1002/alz.13892

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