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Human herpesvirus‐associated transposable element activation in human aging brains with Alzheimer's disease

1 Feb 2025

Abstract excerpt

INTRODUCTION: Human herpesvirus (HHV) has been linked to Alzheimer's disease (AD), but the underlying mechanisms remain unknown. METHODS: We leveraged functional genomics data from Religious Orders Study or the Rush Memory and Aging Project (ROS/MAP) and Mount Sinai Brain Bank (MSBB) brain biobanks and single-cell RNA-sequencing data from HHV-infected forebrain organoids to investigate HHV-infection-associated...

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PMID: 39985481
DOI: 10.1002/alz.14595

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