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Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging

31 May 2023

Abstract excerpt

The primate frontal lobe (FL) is sensitive to aging-related neurocognitive decline. However, the aging-associated molecular mechanisms remain unclear. Here, using physiologically aged non-human primates (NHPs), we depicted a comprehensive landscape of FL aging with multidimensional profiling encompassing bulk and single-nucleus transcriptomes, quantitative proteome, and DNA methylome. Conjoint analysis across...

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PMID: 37261950
DOI: 10.1016/j.celrep.2023.112593

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