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Characterisation of premature cell senescence in Alzheimer’s disease using single nuclear transcriptomics

2 May 2024

Abstract excerpt

Abstract Aging is associated with cell senescence and is the major risk factor for AD. We characterized premature cell senescence in postmortem brains from non-diseased controls (NDC) and donors with Alzheimer’s disease (AD) using imaging mass cytometry (IMC) and single nuclear RNA (snRNA) sequencing (> 200,000 nuclei). We found increases in numbers of glia immunostaining for galactosidase beta (> fourfold) and...

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Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 38695952
DOI: 10.1007/s00401-024-02727-9

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