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Article

SnapHiC: a computational pipeline to identify chromatin loops from single-cell Hi-C data.

Nature methods - 1 Sept 2021

Yu Miao, Abnousi Armen, Zhang Yanxiao, Li Guoqiang, Lee Lindsay, Chen Ziyin, Fang Rongxin, Lagler Taylor M, Yang Yuchen, Wen Jia, Sun Quan, Li Yun, Ren Bing, Hu Ming

Abstract excerpt

Single-cell Hi-C (scHi-C) analysis has been increasingly used to map chromatin architecture in diverse tissue contexts, but computational tools to define chromatin loops at high resolution from scHi-C data are still lacking. Here, we describe Single-Nucleus Analysis Pipeline for Hi-C (SnapHiC), a method that can identify chromatin loops at high resolution and accuracy from scHi-C data. Using scHi-C data from 742...

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Identifiers

PMID: 34446921
DOI: 10.1038/s41592-021-01231-2
PMCID: PMC8440170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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